Inflammation on or in the body can take many forms and can be attributed to various internal or external stimuli. Whether your inflammatory response is due to disease, digestive disorders, poor diet, intense physical activity, or sudden physical trauma, the effects of inflammation have the potential to be quite bothersome for millions of people throughout the world. And while temporary afflictions may cause little to no worry amongst sufferers, prolonged exposure to inflammation has been proven to be responsible for far worse consequences: Inflammaging, anyone?
While there are of course many drugs on the current market that deal with inflammation, how can we trust these substances that are merely addressing symptoms? With a different strategy, one can focus on the optimal functionality of the body and its systems. Our CBD Takeout culture encourages this root cause, whole body approach to wellness. In addition to a low inflammation diet, mental health practices, active lifestyle, etc, CBD products can impact the endocannabinoid receptor activity which plays a part in reducing inflammation.
Let’s examine the ways in which CBD and other similar cannabinoids (present in the hemp plant) work to effectively manage inflammation:
Osteoarthritis & CBD
Osteoarthritis (OA) is multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. It affects 20 million people in the United States alone. In a 2017 study funded by The Arthritis Society, researchers attempted to gather information of CBD’s effectiveness as an inhibitor by focusing on OA-induced lab rats. This study asserts cannabidiol as “the main noneuphoria producing component of the cannabis plant”; this distinction is important to underscore because it solidifies CBD’s stature as a fully medicinal entity and therefore further legitimizes its presence in the pharmaceutical field.
Just like humans, rats have a fully functioning endocannabinoid system that has been widely studied in relation to various ailments. The overarching conclusion in regards to OA and general inflammation is quite positive indeed:
This study showed for the first time that local CBD administration inhibited pain and peripheral sensitisation in established OA. Topical treatment with CBD reduced leukocyte trafficking and joint hyperaemia during the early stages of the injection of sodium monoiodoacetate (MIA). By attenuating this initial inflammatory response with CBD, end-stage OA pain and peripheral neuropathy were abrogated. Thus, CBD may be a safe therapeutic to treat OA pain locally as well as block the acute inflammatory flares that drive disease progression and joint neuropathy.
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Combatting Internal Inflammation
Inflammation can occur inside the body as well, and can therefore be more difficult to address. Inflammatory diseases in the bowels, stomach, lungs, liver and other internal organs are extremely debilitating to their sufferers and their loved ones. Consequently, there are far worse conditions that appear when the body is exposed to inflammation long-term.
In a 2016 study funded by GW Pharmaceuticals, Cambridge, scientists tackled inflammatory bowel disease in mice and the effects of CBD (specifically CBD BDS, for CBD botanical drug substance). Inflammatory bowel disease (IBD) is a chronic immunologically mediated disease that is growing steadily in industrialized countries. The key aspect here is that “effective pharmacotherapies are not always available and existing drugs may cause substantial side-effects leading to poor patient adherence”. While studies in human subjects in relation to THC and IBD relief exist, effectiveness of the non psychoactive CBD hasn’t really entered the conversation. Until now.
Once again, as additional proof of the power of the hemp plant, overwhelmingly positive results accompany the conclusion to these findings. The introduction of orally administered CBD does in fact have the ability to attenuate the severity of inflammation. Furthermore, clinical use is suggested as being effective in intestinal anti-inflammatory activity, and the results also support the rationale of combining CBD with other minor constituents present in Cannabis sativa.
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Cannabidiol, Inflammation & Human Stem Cells
Stem cell research is a topic that has been highly debated and hotly contested in recent times. Scientists discovered ways to derive cells from human embryos in 1998, and have since then been used to study how cells function, reproduce and replenish themselves as needed by the body. This fascinating field as been bolstered by new research, however there are still many uncertainties.
The new bustle of activity within the hemp/CBD research field has therefore also crossed paths with stem cell research – specifically in a 2016 study led by Italian scientists. Here again we see the overwhelmingly positive effects of the introduction of CBD to hGMCSs (Human Gingival Mesenchymal Stem Cells) in relation to inflammation:
“Overall, our results have suggested that CBD negatively regulated the NALP3-inflammasome activation, mainly via a CB1R mechanism. Although a direct modulation of the inflammasome complex by the cannabinoid receptors CB1R and CB2R, has been already investigated by previous studies, its role remains still controversial. Indeed, it has been reported that CB2R activation, by inhibiting the NLRP3-inflammasome pathway, played a protective role in experimental models of inflammatory and autoimmune disorders.”
This is another confirmation of the tried and tested prowess of the miracle compound CBD is it relates to common bodily issues such as inflammation.
Keep following the CBDTakeOut blog for more information on the healing powers of CBD, the latest in products, and for tips on how to make your daily life more comfortable. – Hemp for you Health!